![]() The emergence of this striking negative slope, or steep temporal gradient as described by Fuster, suggests difficulty maintaining mental set. found that impairment on executive tests produced by mixed and dysexecutive MCI patients were similar and remarkable in that performance deteriorated as a function of time to completion and/or test epoch. have shown that patients with amnestic MCI differ from other MCI subtypes on a variety of linguistic as well as memory parameters obtained from a serial list learning test. Second, the investigation of MCI subtypes provides an opportunity to investigate the neurocognitive constructs underlying brain-behavior relationships associated with MCI. Recent research has also shown that when mixed/dysexecutive MCI patients are defined using neuropsychological criteria there tends to be faster progression to dementia than other groups. ![]() For example, past empirical findings suggest greater reliability for the eventual emergence of dementia for amnestic and multi-domain MCI as compared to single domain dysexecutive MCI. The importance of investigating MCI subtypes revolves around several clinical as well as theoretical issues including a greater understanding of conversion to dementia and a clearer appreciation of the brain-behavior relationships that underlie MCI syndromes. Patients diagnosed with MCI can be classified as presenting with single versus multiple domain subtypes. Diagnostic criteria for MCI include the subjective complaint of memory and/or other neurocognitive problems, along with relative preservation of instrumental activities of daily living, in conjunction with objective evidence documenting a decline in memory and/or other neurocognitive abilities. Mild cognitive impairment (MCI) is generally believed to be a prodrome that often results in the emergence of dementia syndromes such as Alzheimer’s disease (AD) and is considered to be a useful construct to identify patients who are potentially at risk for developing a dementing illness.
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